Urea cycle at a glance

Substrate—NH₃

Product--Urea

Site--Liver,

Compartment—Mitochondria & Cytoplasm

Nature--anabolic

Rate limiting enzyme—Carbamoylphosphate  synthase 1

Energy needed—03 ATP

Regulator—N-acetyl glutamate

Importance:

1.      Conversion of toxic NH₃ into no toxic urea

2.      Disposal of two waste products; NH₃ and Co₂

3.      Synthesis of argentine

4.      Synthesis of proline

5.      Interaction of TCA cycle

·         TCA cycle  Co₂ and ATP for urea cycle

·         Urea cycle provides fumerate for TCA cycle