Sites of Anaerobic Glycolysis / EM pathway

• Exercising muscle
• RBC
• Brain
• GIT
• Renal medulla
• Retina
• Skin

Gluconeogenesis at a glance

 Substrate :http://medicalscienceeasy.blogspot.com/2017/12/substrstes-of-gluconeogenesis-at-glance.html

Site: liver 90% , Kidney 10%
Compartment: Mainly cytoplasm ,party in mitochondria
Nature : Anabolic
Rate limiting enzyme : http://medicalscienceeasy.blogspot.com/2017/12/rate-limiting-enzymes-of-gluconeogenesis.html
 ATP needed: 6 ( to produce 1 glucose from substrate)
Source of ATP : Beta Oxydation of fatty acid
 Importance:

• Maintain normal glucose concentration in fasting & starvation
• Disposal of lactic acid & glycerol in normal state

Regulation :http://medicalscienceeasy.blogspot.com/2017/12/factors-regulate-gluconeogenesis.html

Factors regulate Gluconeogenesis

Factors increase / stimulate Gluconeogenesis :

• ATP
• Acetyl CoA
• Cortisol
• Epinephrine
• NADH
• Glucagone

Factors decrease / inhabit Gluconeogenesis :

• AMP
• Fructose -2,6- Bis Phosphate
• Insulin