Interpretation of Hepatitis B virus serological test

We know Hepatitis B virus has 3 antigen and 3 antibodies

Antigens are:

1.       HB sAg (surface antigen)

2.       HB eAg ( envelop antigen )

3.       HB cAg (core antigen , present on the nucleocapsid protein )

Antibodies are:

1.       Anti HBc IgM / HBcAb

2.       Anti HBs IgG / HBs Ab

3.       Anti HBe IgM / HBe Ab

Among these antigen and antibody we found all in serological test except HBcAg.

Interpretations of serological markers:

• ·         HBsAg is the indication of active, chronic infection and convalescent carrier
• ·         HBeAg in blood indicates active replication of virus and the patient is highly infectious
• ·         HBsAb is indicates person with immunity following infection or vaccination.
• ·         HBcAb IgM in blood indicates surest marker of active infection because it also positive in window period.
• ·         HBeAb IgM in blood indicates recovery and its low transmissible.

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