Sunday, 29 May 2016

Hepatitis virus at a glance


Criteria
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
Family
Picorna Virus
Hepadena Virus
Flavi Virus
Incomplete Virus
Calci Virus
Virus type
RNA
DNA
RNA
RNA
RNA
Enveloped
Absent
Present
Present
Present
Absent
Size
27 mm
42 mm
30-60 mm
35 mm
34mm
Mode of transmission
Faeco-oral
Blood transmission
Sexual
Contaminated syringes and needles
Faeco-oral
Tattooing, circumcision
Perinatal



Blood transmission
Sexual
Contaminated syringes and needles
Tattooing, circumcision
Perinatal

Blood transmission
Sexual
Perinatal

Faeco-oral
Incubation period (days )
15-25
50-180
40-120
40-60
20-50
Particles in blood
No
Yes
Yes
Yes
No
Vaccine available
Yes
Yes
No
No
No
Immunoglobulins Useful
Yes
Yes
No
No
No
Chronic Diseases
Never
Often
Often
Often
Never
Age group
Children
All age
All age
All age
Adult
Oncogenicity
No
Yes
Yes
-
No
Common diseases
Infectious hepatitis
Serum hepatitis
Post transfutional hepatitis
Delta hepatitis
Infectious hepatitis
Complications
Fulminant hepatitis (rare )
Chronic hepatitis
Cirrhosis
HCC
Chronic hepatitis
Cirrhosis
HCC
Chronic hepatitis
Liver failure
Fulminant hepatitis (rare )

Fulminant hepatitis (rare )
Diagnosis
Early stage-
*detection of HAV in the stool
*Detection of IgM anti HAV in the serum
Past infection-
* Detection of IgG anti HAV in the serum
*CFT
*RIA and ELISA
Early stage
*Presence of HBs Ag
*presence of IgM Anti HBc
HBeAg
Window period-
presence of Anti-HBc
Remote past- presence of IgG Anti-HBc
Chronic stage with viral activity an infectivity
Persistent HBeAg , HBsAg and presence of IgG Anti-HBc
Resolution-
Appearance of Anti HBe
Detection of Anti-HCV
Detection of Anti-D/Delta
Liver Biopsy
Detection of Anti-HEV

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