Type 2 Hypersensitivity /Cytotoxic Hypersensitivity at a glance

Type-II Hypersensitivity /Cytotoxic Hypersensitivity is immediate antibody mediated hypersensitivity where damage of cell occurs by binding of antigens on cell surface with the help of IgG and IgM.

A. Antibody and Compliment mediated:

1.       Autoimmune haemolytic anaemia

2.       Autoimmune thrombocytopenic purpura

3.       Autoimmune agranulocytosis

4.       Blood transfusion reaction

5.       Drug reaction-chlorpromazine,penicillin,phenacetin,amidopyrine,quinine etc

6.        Erythroblastosis fetalis

7.       Goodpasture syndrome

8.       Pernicious anaemia

9.       Rheumatic fever

10.    Systemic lupus erythematosus

11.    Vasculitis

B.Antibody dependent cellular/cell mediated cytotoxicity:

1.       Graft rejection

2.       Lysis of parasites

3.       Lysis of tumor cells

C. Antibody mediated/dependent cellular dysfunction:

1.       Insulin resistance Diabetes Mellitus

2.        Graves diseases

3.       Myasthenia gravis

4.       Pemphigus vulgaris.



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