Type-IV hypersensitivity / Delayed Hypersensitivity / cell mediated Hypersensitivity at a glance

Types:

A. Delayed – type hypersensitivity when it is predominantly mediated by CD4 T cell

B. T cell mediated cytotoxicity when it is predominantly mediated by CD8 T cell

Cell involved:  Lymphocyte and Monocyte-macrophage series

        Examples:

·         Tuberculin test (CD4 T cell)

·         Graft rejection (CD4 T cell)

·         Contact hypersensitivity or dermatitis (CD8 T cell)

·          Lepromin test

·         Granulomatous inflammations

·         Type-I diabetes mellitus

·         Rheumatoid arthritis

·         Guillain-Barre syndrome

·         Multiple sclerosis






Collected & Concise only for postgraduate student